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You can access and purchase the full, official document through the following authoritative sources:
The standard outlines the specific American Type Culture Collection (ATCC) strains required to test non-exempt media, detailing acceptable viability protocols and inoculation methods to ensure standard results. Why Labs Need the Official PDF
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Label each type as either Exempt or Non-Exempt based on M22-A3 criteria.
Testing with specific ATCC control strains to ensure expected growth. You can access and purchase the full, official
While many media types are designated as "exempt" under M22A3, laboratories are still required to visually inspect plates or tubes and adhere to strict inventory management (i.e., not using expired media). Furthermore, for non-exempt media or for media prepared in-house, the user is required to perform routine QC testing using positive and negative reacting organisms as recommended by the CLSI. The Concept of Exempt vs. Non-Exempt Media
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The guidelines within CLSI M22-A3 are built upon fundamental quality control principles that are essential for any microbiology laboratory. The core idea is that the quality of the culture medium directly impacts the validity of any test result. The standard provides concrete procedures to assess this quality in several ways: